THERAPY DOSSIER · th-9fa8387345a4

Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) hydrogel scaffold, prepared by bulk radical copolymerisation of 2-hydroxyethyl methacrylate, cholesterol methacrylate and ethylene dimethacrylate with ammonium oxalate crystals as porogen, with hydrolysed 2-[(methoxycarbonyl)methoxy]ethyl methacrylate introducing carboxyl groups to tune swelling and softness

Device · CHEMBL NOT QUERIED: this is a bespoke synthetic polymer DEVICE, a superporous cholesterol-modified pHEMA hydrogel scaffold defined by its copolymerisation recipe and pore architecture rather than by a single molecular entity, so no ChEMBL drug record can exist.

Device Suggest a correction

Evidence & regulatory context

Mechanism: CHEMBL NOT QUERIED: this is a bespoke synthetic polymer DEVICE, a superporous cholesterol-modified pHEMA hydrogel scaffold defined by its copolymerisation recipe and pore architecture rather than by a single molecular entity, so no ChEMBL drug record can exist.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21953978 ↗2011Reported benefit

Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair.

RatSpinal cord injuryHemisection / partialWistarMaleImplanted into the spinal cord to bridge the hemisection cavityImplanted at the time of acute hemisection injury, with histological assessment…

Model: Acute spinal cord hemisection creating a cavity bridged by an implanted hydrogel; complemented by in vitro culture of rat mesenchymal stem cells on the scaffolds

The hydrogels supported in vitro adhesion and proliferation of rat mesenchymal stem cells, and at 4 weeks after implantation showed good incorporation into surrounding tissue with progressive connective tissue infiltration and ingrowth of neurofilaments, Schwann cells and blood vessels into the por…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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