c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice.

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice.

Model: Acetaminophen or GalN/TNF-alpha-induced acute liver injury

Silencing mitochondrial Sab inhibited sustained JNK activation and protected against acetaminophen and TNF-induced acute liver injury.

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