Evidence & regulatory context
- Mechanism
- Adenovirus-delivered shRNA knockdown construct against SH3BP5/Sab; not a ChEMBL-tractable entity (no small molecule or named biologic). No clinical product exists for this construct, so no CTgov match. resolved=false, to_trial=false.
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseChemical/toxinC57BLMale
Model: Acetaminophen or GalN/TNF-alpha-induced acute liver injury
Silencing mitochondrial Sab inhibited sustained JNK activation and protected against acetaminophen and TNF-induced acute liver injury.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
