PRECLINICAL PUBLICATION · 2011

Activated platelets in heparinized shed blood: the second hit of acute lung injury in trauma/hemorrhagic shock models.

Rat / Haemorrhage/shock

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21841533 ↗2011Mixed findings

RatHaemorrhage/shockControlledSprague-DawleyMaleClopidogrel pretreatment before trauma/haemorrhagic shock

Model: Trauma/haemorrhagic shock (MAP 30 mmHg x 45 min) with acute lung injury

Returning heparinized shed blood worsened acute lung injury via activated platelets, while P2Y12 antagonist pretreatment was protective.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.