THERAPY DOSSIER · th-68470982d4fa

Clopidogrel (platelet P2Y12 antagonist); returned heparinized shed blood

Drug · Irreversible antagonist of the platelet P2Y12 purinergic receptor; prodrug requiring hepatic CYP activation.

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Irreversible antagonist of the platelet P2Y12 purinergic receptor; prodrug requiring hepatic CYP activation.
Target: CHEMBL2001 (P2Y purinoceptor 12)
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: 1997
Development stage: Not recorded
ChEMBL record: CHEMBL1771 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Clopidogrel; Plavix; SR 25990; R-130964; NSC-758613; Clopidogrel bisulfate; Iscover
Note: Not recorded

Clinical trials 7

5 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00421252 ↗Injury indicationPHASE4terminated

Pre-treatment with 600 mg clopidogrel and ischaemic/haemorrhagic complications in elective PCI

Coronary Artery Disease · Myocardial Ischemia · Bleeding

Enrolment: 18 · Results not recorded

NCT02640794 ↗Injury indicationPHASE4completed

Aspirin vs aspirin + clopidogrel after TAVI (ARTE trial)

Aortic Valve Disease · Myocardial Infarction · Stroke · Bleeding

Enrolment: 222 · Results not recorded

NCT05223335 ↗Injury indicationPHASE4completed

Clopidogrel monotherapy in high bleeding risk patients undergoing PCI

Bleeding Complications

Enrolment: 98 · Results not recorded

NCT01216150 ↗Injury indicationPhase not recordedcompleted

Clopidogrel with aspirin: postoperative bleeding and platelet function in coronary surgery (ICARE)

Coronary Surgery · Hemorrhage

Enrolment: 150 · Results not recorded

NCT02635230 ↗Injury indicationPhase not recordedunknown

Registry: oral anticoagulants and P2Y12 inhibitors in AF or valve prosthesis undergoing revascularisation

Atrial Fibrillation · Acute Coronary Syndromes · Stroke · Bleeding

Enrolment: 2200 · Results not recorded

NCT03103685 ↗PHASE4unknown

Continue vs stop P2Y12 inhibitor on bleeding during dental procedures

Dental Diseases · Antiplatelet Agents

Enrolment: 428 · Results not recorded

NCT01561950 ↗PHASE1terminated

Recombinant FVIIa to mitigate clopidogrel antiplatelet-mediated bleeding

Haemostasis · Healthy

Enrolment: 91 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21841533 ↗2011Mixed findings

Activated platelets in heparinized shed blood: the second hit of acute lung injury in trauma/hemorrhagic shock models.

RatHaemorrhage/shockControlledSprague-DawleyMaleClopidogrel pretreatment before trauma/haemorrhagic shock

Model: Trauma/haemorrhagic shock (MAP 30 mmHg x 45 min) with acute lung injury

Returning heparinized shed blood worsened acute lung injury via activated platelets, while P2Y12 antagonist pretreatment was protective.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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