PRECLINICAL PUBLICATION · 2011

Mechanisms of dendritic spine remodeling in a rat model of traumatic brain injury.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21838518 ↗2011Reported benefit

RatTBIFluid percussionSprague-DawleyMaleSingle bolus 1 h post-TBI

Model: Lateral fluid percussion traumatic brain injury

The calcineurin inhibitor FK506 blocked TBI-induced cofilin changes in some brain regions, implicating calcineurin in dendritic spine remodelling.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.