Effects of a single dose of methylprednisolone versus three doses of rosiglitazone on nerve growth factor levels after spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyIntraperitonealRosiglitazone 2 mg/kg; methylprednisolone 30 mg/kg5 min, 6 h and 24 h after surgery (rosiglitazone); 5 min (methylprednisolone)
Model: Spinal cord contusion injury with laminectomy
Rosiglitazone increased nerve growth factor expression more than methylprednisolone and improved early motor recovery after spinal cord injury.
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