The antinociceptive effect of the asthma drug ibudilast in rat models of peripheral and central neuropathic pain.
RatSpinal cord injuryCompressionSprague-DawleyMaleIntraperitoneal10 mg/kg30-32 days post-SCI; 14-16 days post-CCI
Model: Mid-thoracic spinal cord injury (clip) and sciatic chronic constriction injury
Ibudilast ameliorated tactile hypersensitivity in both central spinal cord injury and peripheral neuropathic pain models.
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