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← Studies/PMID 21772666
PRECLINICAL PUBLICATION · 2011

Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-kB pathway after traumatic brain injury in the rat.

Rat / TBI

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PMID 21772666 ↗2011Reported benefit

Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-kB pathway after traumatic brain injury in the rat.

RatTBIWeight-drop / impact-accelerationSprague-DawleyMalen = 30 per groupIntraperitoneal75 mg/kg5 min, 1 h and 6 h after TBI

Model: Weight-drop parietal cortical contusion traumatic brain injury

Ethyl pyruvate reduced HMGB1/TLR4/NF-kB inflammation, brain oedema and apoptosis and improved beam walking after traumatic brain injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.