Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases.

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases.

Model: Peripheral nerve injury (neuropathic pain); formalin tissue injury

Mice lacking all three NOS isoforms showed reduced spinal microglial activation and neuropathic pain after nerve injury, and pharmacological NOS/nNOS inhibition attenuated allodynia.

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