THERAPY DOSSIER · th-6133503f0189

L-NAME

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion · Spinal cord injury · Other · Wound · Radiation · TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Preclinical/no trial
ChEMBL record: CHEMBL7890 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: L-NAME; Ng-nitro-L-arginine methyl ester
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 10

3 studies reported at therapy level; 10 evidence entries itemised.

PMID 21725496 ↗2011Reported benefit

Contribution of nitric oxide synthase (NOS) activity in blood-brain barrier disruption and edema after acute ischemia/reperfusion in aortic coarctation-induced hypertensive rats.

RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntraperitoneal1 mg/kgBefore MCAO

Model: Middle cerebral artery occlusion ischaemia/reperfusion in acute hypertensive (aortic coarctation) rats

L-NAME reduced cerebral infarction, oedema and blood-brain barrier disruption after ischaemia/reperfusion in acutely hypertensive rats.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

PMID 28091928 ↗2017Outcome unclear

Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord.

RatSpinal cord injuryContusionOutbredMale and femaleAcute period after spinal cord injury; timing selected from electron paramagnet…

Model: Experimental contusion injury of the spinal cord

L-NAME given during the acute period after spinal cord contusion sharply reduced the intensity of evoked motor responses and produced a more pronounced increase in excitability of peripheral motor structures. The authors interpret this as evidence that the nitric oxide system regulates stress-induc…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

PMID 21756313 ↗2011Reported benefit

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases.

MouseOthern/i/eNOS triple knockout and wild-typeMale

Model: Peripheral nerve injury (neuropathic pain); formalin tissue injury

Mice lacking all three NOS isoforms showed reduced spinal microglial activation and neuropathic pain after nerve injury, and pharmacological NOS/nNOS inhibition attenuated allodynia.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

PMID 15223606 ↗2004