HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats.
RatHaemorrhage/shockUnspecifiedSprague-Dawley and WistarMaleIntraperitoneal (in vivo)10-100 microM (slice cultures)After haemorrhage
Model: Intracerebral haemorrhage (type IV collagenase injection into striatum); thrombin slice cultures
Glycyrrhizin, an HMGB1 inhibitor, attenuated brain oedema, neuronal loss and behavioural deficits after intracerebral haemorrhage in rats.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.