Endothelin receptor-A (ETa) inhibition fails to improve neonatal hypoxic-ischemic brain injury in rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-Dawleyn = 913 mg/kgPost-treatment (after injury)
Model: Neonatal hypoxic-ischaemic brain injury (Rice-Vannucci: carotid ligation + 8% oxygen 2 h)
ETA receptor blockade with ABT-627 had no effect on brain oedema, infarct volume or neurological outcomes after neonatal hypoxic-ischaemic injury in rats.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.