PRECLINICAL PUBLICATION · 2011

Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion.

Rat / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Calcitonin gene-related peptide (CGRP)

PMID 21718723 ↗2011Reported benefit

Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion.

RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleIntraperitoneal3 microg/kgAt the beginning of reperfusion

Model: Transient middle cerebral artery occlusion (2 h) with 46 h reperfusion

CGRP reduced brain oedema, infarct volume and blood-brain barrier disruption after focal cerebral ischaemia-reperfusion in rats, partly via AQP4 downregulation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.