Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats.

Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats.

Model: Permanent middle cerebral artery occlusion focal cerebral ischaemia

Peripheral human adrenomedullin combined with AMBP-1 reduced infarct volume, apoptosis and inflammation after ischaemic stroke in rats, an effect not seen with either agent alone.

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