Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3 expression and decreasing spinal microglial activation.
RatOtherSprague-DawleyMalen = 66Intrathecal2% lidocaine, 50 microLPretreatment (before nerve injury)
Model: L5 spinal nerve ligation (neuropathic pain)
Intrathecal lidocaine pretreatment attenuated acute neuropathic pain after spinal nerve ligation by reducing Nav1.3 upregulation and spinal microglial activation, with effects lasting 3 days.
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