Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
RatOtherSprague-DawleyFemale7 days after surgery
Model: Spared nerve injury (neuropathic pain); paw-withdrawal heat (acute pain)
Ketamine, norketamine and the NR2B-selective antagonist traxoprodil all produced antinociception and long-lasting relief of allodynia, with traxoprodil showing separation from side effects.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.