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PRECLINICAL PUBLICATION · 2011

Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21606828 ↗2011Reported benefit

Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.

RatOtherSprague-DawleyFemale7 days after surgery

Model: Spared nerve injury (neuropathic pain); paw-withdrawal heat (acute pain)

Ketamine, norketamine and the NR2B-selective antagonist traxoprodil all produced antinociception and long-lasting relief of allodynia, with traxoprodil showing separation from side effects.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.