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PRECLINICAL PUBLICATION · 2011

Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental brain injury.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21584844 ↗2011Reported benefit

Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental brain injury.

RatTBIControlled cortical impactSprague-DawleyMaleIntraperitonealFollowing cortical contusion

Model: Cortical contusion (traumatic brain injury)

Ro5-4864, a TSPO ligand, reduced intracranial pressure, improved cerebral metabolism and limited mitochondrial damage and lesion size after cortical contusion in rats.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.