THERAPY DOSSIER · th-0e4b3298d52e

Ro5-4864

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21584844 ↗2011Reported benefit

Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental brain injury.

RatTBIControlled cortical impactSprague-DawleyMaleIntraperitonealFollowing cortical contusion

Model: Cortical contusion (traumatic brain injury)

Ro5-4864, a TSPO ligand, reduced intracranial pressure, improved cerebral metabolism and limited mitochondrial damage and lesion size after cortical contusion in rats.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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