PRECLINICAL PUBLICATION · 2011

Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21549006 ↗2011Mixed findings

MouseTBIControlled cortical impactC57BL/6JMaleintraperitoneal16 mg/kg1 and 6 h after surgery

Model: bilateral controlled cortical impact injury

Progesterone down-regulated three injury-induced target genes (Ccl2, IL-1b, Cxcl10) but did not inhibit TLRs or their adaptors after TBI.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.