PRECLINICAL PUBLICATION · 2011

Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21511011 ↗2011Reported benefit

MouseEndotoxin/LPSICRMaleintraperitoneal1 or 3 mg/kgafter LPS

Model: intratracheal lipopolysaccharide acute pulmonary injury

Rac inhibition with NSC23766 reduced neutrophil infiltration, pro-inflammatory mediators and vascular permeability in LPS-induced lung injury.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.