Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
2 studies reported at therapy level; 2 evidence entries itemised.
Model: intratracheal lipopolysaccharide acute pulmonary injury
Rac inhibition with NSC23766 reduced neutrophil infiltration, pro-inflammatory mediators and vascular permeability in LPS-induced lung injury.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Streptococcal M1 protein-induced acute lung injury, 15 ug M1 protein in phosphate-buffered saline intravenously
NSC23766 at 5 mg/kg reduced lung oedema by 87% (wet to dry ratio 5.2 +/- 0.06 to 4.7 +/- 0.03), lung myeloperoxidase by 48% and lavage neutrophils by 65%, and cut CXCL1 and CXCL2 formation by more than 85% without affecting neutrophil Mac-1 up-regulation.
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
