Estradiol worsens the syndrome of ischemia-reperfusion injury in an experimental lung transplantation model.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMalen = 25 rats (5 per group)single doseestradiol 25 mg/kg; desferrioxamine 20 mg/kg; melatonin 10…50 min before reperfusion
Model: left lung transplantation ischaemia-reperfusion (6 h ischaemia)
Estradiol worsened injury and caused severe oedema, whereas desferrioxamine and melatonin had no effect on injury or rejection.
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