Vitamin E ameliorates iodine-induced cytotoxicity in thyroid.
RatChemical/toxinOral (in diet)25-, 50- or 100-fold physiological doseConcurrent with iodine supplementation
Model: Iodine-induced thyroid cytotoxicity; goiter induced by 12-week low-iodine diet then twofold physiological dose of iodine in drinking water
Vitamin E supplementation partly ameliorated iodine-induced thyroid cytotoxicity, with a 50-fold dose optimal, but did not reduce involuting gland weight.
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