Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.
MixedIschaemia-reperfusionCerebral (MCAO/stroke)ICR mice; Sprague-Dawley ratsMaleintraperitoneal (mice); oral (rats)mice 0.1 mg/kg; rats 0.5 mg/kgfor 5 days after ischaemia
Model: transient middle cerebral artery occlusion focal cerebral ischaemia
Montelukast attenuated behavioural dysfunction, infarct volume, atrophy and neuron loss after focal cerebral ischaemia in mice and rats.
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