Glutamate antagonism fails to reverse mitochondrial dysfunction in late phase of experimental neonatal asphyxia in rats.
RatOther20 mg/kg/dayAfter anoxic exposure
Model: Neonatal asphyxia; two 10-min episodes of anoxia (100% N2) 24 h apart
Ketamine reversed elevated glutamate and nitric oxide but failed to reverse anoxia-induced mitochondrial dysfunction in the secondary phase.
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