PRECLINICAL PUBLICATION · 2011

A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21273554 ↗2011Reported benefit

MouseOtherFemaleLocal (adherent methylcellulose patch releasing peptide over <48 h)At time of cryoinjury

Model: Left ventricular cryoinjury

alphaCT1 preserved Cx43 at intercalated disks, reduced gap junction remodeling and lowered inducible arrhythmia after ventricular injury.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.