THERAPY DOSSIER · th-cb75b90d14be

alphaCT1 (connexin43 carboxyl terminus mimetic peptide)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04684121 ↗Injury indicationPHASE2withdrawn

Granexin gel to improve burn wound healing

Second Degree Burn · Thermal Burn

Enrolment: 0 · Results not recorded

NCT02667327 ↗PHASE3terminated

Phase 3 study of Granexin gel in diabetic foot ulcer (GAIT 1)

Diabetic Foot Ulcers

Enrolment: 124 · Results not recorded

NCT04331080 ↗PHASE2/PHASE3completed

Granexin gel to reduce scar formation after bilateral anchor incision breast surgery

Scarring · Mammoplasty

Enrolment: 184 · Results not recorded

NCT02652572 ↗PHASE1completed

Open-label pharmacokinetic study of Granexin gel (alphaCT1) in venous leg ulcers

Venous Leg Ulcer

Enrolment: 10 · Results not recorded

NCT02652754 ↗PHASE1completed

Open-label pharmacokinetic study of Granexin gel in diabetic foot ulcers

Diabetic Foot Ulcers

Enrolment: 16 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21273554 ↗2011Reported benefit

A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury.

MouseOtherFemaleLocal (adherent methylcellulose patch releasing peptide over <48 h)At time of cryoinjury

Model: Left ventricular cryoinjury

alphaCT1 preserved Cx43 at intercalated disks, reduced gap junction remodeling and lowered inducible arrhythmia after ventricular injury.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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