PRECLINICAL PUBLICATION · 2011

Methylprednisolone exacerbates acute critical illness-related corticosteroid insufficiency associated with traumatic brain injury in rats.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Methylprednisolone

PMID 21262204 ↗2011Reported harm

Methylprednisolone exacerbates acute critical illness-related corticosteroid insufficiency associated with traumatic brain injury in rats.

RatTBIFluid percussionWistarMale5-30 mg/kg (high dose)After injury

Model: Fluid percussion injury (traumatic brain injury)

High-dose methylprednisolone increased hypothalamic and pituitary apoptosis and exacerbated acute corticosteroid insufficiency and mortality after TBI.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.