Reducing pulmonary injury by hyperbaric oxygen preconditioning during simulated high altitude exposure in rats.
RatOtherWistarMaleHyperbaric chamber100% O2 at 2.0 ATA for 1 hour per dayPreconditioning before high altitude exposure
Model: Simulated high altitude exposure (6000 m for 24 h in hypobaric chamber) inducing acute lung injury
Hyperbaric oxygen preconditioning reduced high altitude-induced lung injury scores and restored AQP1 and AQP5 expression in rat lung.
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