PRECLINICAL PUBLICATION · 2011

Tumor necrosis factor-alpha antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Etanercept

PMID 21224756 ↗2011Reported benefit

Tumor necrosis factor-alpha antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injury.

RatSpinal cord injuryUnspecifiedSprague-DawleyMaleIntraperitoneal1 hour after injury

Model: Thoracic spinal cord injury

Etanercept reduced neuronal and oligodendroglial apoptosis, limited tissue damage, promoted myelination and improved hindlimb locomotion after spinal cord injury.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.