PRECLINICAL PUBLICATION · 2010

Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury.

Rat / TBI

The same PMID has conflicting title or year metadata in its therapy associations. Each original extraction is preserved below; the heading uses the first source occurrence.

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Melatonin

PMID 21056621 ↗2010No effect reported

Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury.

RatTBIControlled cortical impactSprague-DawleyMaleIntraperitoneal injectionAcute post-injury (melatonin) then daily (minocycline)

Model: Controlled cortical impact (1.5 mm) traumatic brain injury

Neither melatonin, minocycline nor their combination significantly improved cognitive or histological outcomes after TBI.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

Minocycline

PMID 21056621 ↗2011No effect reported

Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury

RatTBIControlled cortical impactSprague-DawleyMaleIntraperitoneal injectionAcute post-injury (melatonin) then daily (minocycline)

Model: Controlled cortical impact (1.5 mm) traumatic brain injury

Neither melatonin, minocycline nor their combination significantly improved cognitive or histological outcomes after TBI.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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