PRECLINICAL PUBLICATION · 2010

An IL-1 receptor antagonist blocks a morphine-induced attenuation of locomotor recovery after spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 20974246 ↗2010Mixed findings

RatSpinal cord injuryContusionSprague-DawleyMaleIntrathecal3 ug intrathecal (morphine 20 mg/kg or 90 ug)Acute phase (day 1 post-injury)

Model: Spinal cord contusion injury

IL-1ra blocked morphine-induced attenuation of locomotor recovery but alone worsened recovery and increased tissue loss.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.