Chronic blockade of interleukin-1 (IL-1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury.
MouseOtherMaleSubcutaneous osmotic pump and single injection2 days before injury (chronic) or 4 days after (acute)
Model: Peripheral nerve injury (spinal nerve transection and neuroma models)
IL-1ra prevented and attenuated neuropathic pain behaviour and reduced ectopic neuronal activity after nerve injury.
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