PRECLINICAL PUBLICATION · 2010

Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis.

Rat / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 20709317 ↗2010Reported benefit

RatChemical/toxinSprague-DawleyMale1 mg/kg1 h after onset of pancreatitis

Model: Cerulein-induced acute pancreatitis with associated lung injury

Estradiol attenuated pancreatitis-associated lung injury via the Akt pathway, an effect abolished by Wortmannin.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.