PRECLINICAL PUBLICATION · 2010

mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn.

Rat / Burn

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 20594757 ↗2010Reported benefit

RatBurnUnspecifiedSprague-DawleyIntraperitoneal0.4 mg/kg4 days after burn, 2 h before glucose clamp

Model: 30 percent TBSA full thickness burn

mTOR inhibition with rapamycin reduced IRS-1 serine307 phosphorylation and partly prevented burn-induced insulin resistance.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.