Burn-induced heart failure: lipopolysaccharide binding protein improves burn and endotoxin-induced cardiac contractility deficits.
RatBurnScaldSprague-DawleyMaleIn vitro cardiomyocyte co-cultureConcentrations 1 to 30 percent by volume (LPS 50 ug/mL)Cardiomyocytes isolated 24 h post-injury
Model: 30 percent TBSA scald burn with LPS challenge (cardiomyocytes studied in vitro)
High-dose rLBP restored cardiomyocyte sarcomere contractile function after burn and endotoxin exposure in vitro.
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