THERAPY DOSSIER · th-fe8dca665116

Porous crosslinked collagen-glycosaminoglycan coprecipitate membrane (artificial skin)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05344521 ↗Injury indicationPHASE1not yet recruiting

A Phase I, Single-blind, Randomized Study of the Safety and Efficacy of Cellularized Integra Using Autologous Burn-derived Stem Cells

Burns

Enrolment: 29 · Results not recorded

NCT04543240 ↗Injury indicationPhase not recordedunknown

The Relationship Between Bacterial Load and the Clinical Outcomes for Integra in Operative Wounds

Wounds and Injuries

Enrolment: 54 · Results not recorded

NCT05311124 ↗Injury indicationNAunknown

Direct Application of Integra Bilayer Matrices on Bare Calvarium Without Preliminary Burring

Wound Care · Pressure Ulcer · Venous Ulcer · Surgical Wound · Trauma Wounds

Enrolment: 10 · Results not recorded

NCT01060670 ↗NAcompleted

A Multi-Center, Randomized, Controlled Clinical Trial to Evaluate The Safety and Effectiveness of Integra Dermal Regeneration Template for the Treatment of Neuropathic Diabetic Foot Ulcers

Neuropathic Diabetic Ulcer - Foot

Enrolment: 545 · Results not recorded

NCT03971968 ↗Phase not recordedcompleted

Observational Study for the Long-Term Effects of a Dermal Substitute on Patients With Facial Burns

Cicatrix

Enrolment: 8 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 6987234 ↗1980Reported benefit

Design of an artificial skin. I. Basic design principles.

Guinea pigWoundTopical application as a wound coveringApplied to freshly prepared full-thickness wounds

Model: Large full-thickness excisional skin wounds

The membranes protected full-thickness wounds from infection and fluid loss for more than 25 days without rejection, strongly retarded wound contraction and were replaced by newly synthesised stable connective tissue.

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

Loading the evidence…