THERAPY DOSSIER · th-fe7737278eb6

Silver nanoparticle immobilised on nanoscale silicate platelets (AgNP/NSP) wound dressing

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07147790 ↗Phase not recordedenrolling by invitation

Negative-Pressure Wound Therapy Integrated With Silver Nanoparticle Spray Versus NPWT in Post-Revascularisation Diabetic Foot Wound Management

Limb Ischaemia · Diabetes Mellitus

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22693632 ↗2012Reported benefit

Nanohybrids of silver particles immobilized on silicate platelet for infected wound healing.

MouseBurnUnspecifiedBALB/cMalen = Seven treatment groups; results expressed as mean and stand…Topical, applied to the wound bed as a dressing2 mg/ml silver preparation coated on the dressing, giving a…One day after wounding and bacterial dressing application

Model: Staphylococcus aureus infected deep partial-thickness burn (iron plate 1.5 x 1.5 cm at 180 degrees C for 20 s) and full-thickness 1.5 x 1.5 cm excision wound

AgNP/NSP was superior for wound appearance and gave the smallest excision wound area (5 plus or minus 3.5 mm) at days 5, 7 and 15, but wound healing rates, VEGF-A and TGF-beta1 levels were similar to Aquacel and silver sulfadiazine. The nanohybrid showed a trend to lower cytotoxicity at 8.75 ppm si…

Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.

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