THERAPY DOSSIER · th-fd3d81780c48

Purified opsonic fibronectin

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01279369 ↗Injury indicationPhase not recordedterminated

The Use of Fetal Fibronectin (fFN) in Predicting Preterm Delivery Due to Abruptio Placenta in Patients With Minor Maternal Trauma.

Pregnancy Related · Trauma · Abruptio Placentae

Enrolment: 3 · Results not recorded

NCT00005796 ↗PHASE1completed

A Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase

Bone Marrow Suppression · Brain and Central Nervous System Tumors · Drug/Agent Toxicity by Tissue/Organ

Enrolment: 10 · Results not recorded

NCT04971369 ↗NAunknown

Safety Study of 89Zr-NY001 PET Imaging in Patients With Fibronectin ED-B Positive Solid Tumors

Solid Tumor, Adult

Enrolment: 20 · Results not recorded

NCT00156000 ↗Phase not recordedwithdrawn

Fetal Fibronectin (fFN) and Salivary Estriol (E3) in the Prediction of Preterm Birth in Women With Twin Pregnancies Receiving 17-Alpha-Hydroxyprogesterone Caproate or Placebo

Preterm Delivery · Preterm Birth

Enrolment: 0 · Results not recorded

NCT01955148 ↗Phase not recordedunknown

Prospective Phase III Evaluation Of Fetal Fibronectin In A High Risk Asymptomatic Population For The Prediction Of Spontaneous Preterm Birth

Pre-term Birth

Enrolment: 1210 · Results not recorded

NCT00883324 ↗Phase not recordedcompleted

A Phase IIIB Comparison of Fetal Fibronectin (fFN) Specimen Collection Methodologies: With Speculum Versus Without Speculum

Preterm Delivery

Enrolment: 329 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 6824434 ↗1983Mixed findings

Correction of serum opsonic defects after burn and sepsis by opsonic fibronectin administration.

RatBurnUnspecifiedInbred rats, strain not specifiedAfter burn injury, once opsonic fibronectin depletion had occurred (depletion e…

Model: Thermal burn injury with superimposed moderate or severe sepsis (staphylococcal challenge)

Burn injury acutely depleted opsonic fibronectin from 341 (SE 30) to 98 (SE 7) mg/L. Repletion corrected levels when sepsis was moderate, but with severe sepsis levels only reached 121 (SE 18) mg/L. The in vitro serum opsonic deficit improved partially, from 2.2 to 6.7 per cent of injected dose per…

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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