THERAPY DOSSIER · th-fb9042108ada

Human amniotic membrane fragment

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04030754 ↗Injury indicationPHASE2/PHASE3completed

Amniotic Membrane vs Duoderm Dressings in Pediatric Burn Patients: RCT

Burns

Enrolment: 172 · Results not recorded

NCT00592189 ↗Injury indicationEARLY_PHASE1completed

Fetal (Amniotic) Membrane as a New Coverage Material for Wounds

Wounds

Enrolment: 1164 · Results not recorded

NCT03379324 ↗NAunknown

Arthroscopic Rotator Cuff Repair With and Without Injectable Amnion Allograft

Rotator Cuff Tear

Enrolment: 260 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28300874 ↗2017Reported benefit

Amniotic membrane as an option for treatment of acute Achilles tendon injury in rats.

RatOtherWistarMalen = 60 rats in 3 groups, subdivided across 4 time pointsLocal application to the injured tendonAt the time of the surgical tendon injury

Model: Surgical acute Achilles tendon injury

Tendons treated with human amniotic membrane showed better collagen fibre alignment at 14 days and features of mature connective tissue at 28 days, with reduced inflammatory response and intense fibroblast proliferation compared with untreated injured tendons. FTIR distinguished all three groups at…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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