The Administration of the New Pyrimidine Derivative-4-{2-[2-(3,4-Dimethoxyphenyl)-Vinyl]-6-Ethyl-4-Oxo-5-Phenyl-4H-Pyrimidine-1-Il}Benzsulfamide Restores the Activity of Brain Cells in Experimental Chronic Traumatic Encephalopathy by Maintaining Mitochondrial Function.
MixedTBIWeight-drop / impact-accelerationWistar rats for the injury model; BALB/c mice for single-dose toxicity testingMalen = 70 BALB/c male mice for toxicity testing and 40 Wistar male…Oral, by atraumatic gavage needle100 mg/kg; reference drug choline alfoscerate also at 100 m…Given 30 min after each injury
Model: Chronic traumatic encephalopathy produced by free fall of a 150 g load from a height of 50 cm onto the parietal region of the rat skull, repeated once daily for 7 days, with testing on day 8
The pyrimidine derivative preserved cognitive performance and reduced sensorimotor deficit by 46.5%, raised cerebral blood flow by 35.6% and increased brain ATP 4.2-fold relative to untreated injured rats. It also lowered serum GFAP, NSE and S100beta and brain beta-amyloid, and restored mitochondri…
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