THERAPY DOSSIER · th-fa37bdc97bc4

Tong-Xie-Yao-Fang (four-herb decoction, 6:4:3:2 proportions, 4.92 g/mL)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02538692 ↗PHASE2/PHASE3completed

Tong-Xie-Yao-Fang Granules for Diarrhea-predominant Irritable Bowel Syndrome

Diarrhea-predominant Irritable Bowel Syndrome

Enrolment: 160 · Results not recorded

NCT06737666 ↗PHASE1recruiting

Effects of Tong-Xie-Yao-Fang in Regulating Treg/Th17 Imbalance of Diarrhea-predominant IBS

Diarrhea-predominant Irritable Bowel Syndrome

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33344641 ↗2020Reported benefit

Efficacy of Compound Herbal Medicine Tong-Xie-Yao-Fang for Acute Radiation Enteritis and Its Potential Mechanisms: Evidence from Transcriptome Analysis.

RatRadiationSprague-DawleyMalen = 48 rats in total, four groups of n = 12; three jejunal samp…Oral gavage4.92 g per 100 g body weight, given as 2 mL per 100 g per d…Started on day 1 after irradiation

Model: Acute radiation enteritis induced by a single whole-abdominal irradiation of 10 Gy using a linear accelerator

Tong-Xie-Yao-Fang significantly increased jejunal villus height and full thickness versus the irradiated control and improved mental state and food intake, with crypt depth and mucosal thickness unchanged, and an effect comparable with glutamine.

Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.

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