The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis.
MouseWoundC57BL/6 (mouse); AB strain and mpeg.mCherryCAAX SH378 mpx:GFP i114 transgenic line (zebrafish)n = 12 zebrafish larvae per experimental group unless otherwise…Topical10 microM applied to the mouse wound; 10 microM used in zeb…Applied to the mouse wound immediately after excision; applied to human skin 24…
Model: 6 mm full-thickness excisional skin wound in mice, zebrafish larval tail fin amputation and regeneration, and human acute irritant contact dermatitis induced by 5% sodium dodecyl sulfate patches on the volar forearm
Lawsone activated AhR in keratinocytes, zebrafish larvae and human skin, inhibiting keratinocyte proliferation and promoting cornified envelope differentiation. It delayed mouse wound healing and impaired zebrafish fin regeneration and neutrophil recruitment, yet topical Lawsone cream accelerated r…
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