THERAPY DOSSIER · th-f76b740b0bfd

NO-711 (GABA transporter-1 uptake inhibitor); alpha2 GABA-A subunit antisense oligodeoxynucleotides

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00236054 ↗PHASE3completed

Gabitril (tiagabine) up to 16 mg/Day in Adults With Generalized Anxiety Disorder

Generalized Anxiety Disorder

Enrolment: 440 · Results not recorded

NCT00214994 ↗PHASE3completed

12-Month Open-Label Safety and Efficacy of GABITRIL (tiagabine) in Adults With Generalized Anxiety Disorder

Anxiety Disorders

Enrolment not recorded · Results not recorded

NCT02387710 ↗PHASE2completed

Inducing Slow Wave Sleep to Treat Obstructive Sleep Apnea (tiagabine)

Sleep Apnea, Obstructive

Enrolment: 18 · Results not recorded

NCT00086255 ↗PHASE2completed

Tiagabine for the Treatment of Cocaine Dependence

Cocaine-Related Disorders

Enrolment: 140 · Results not recorded

NCT01904487 ↗PHASE1completed

Characterization of [11C]Flumazenil to Image GABA Transmission (tiagabine challenge)

Alcoholism

Enrolment: 11 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26164299 ↗2015Mixed findings

Silencing the alpha2 subunit of gamma-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury.

RatCrushPeripheral-nerve crushSprague-DawleyFemale (retired breeders)n = 4 to 10 rats per behavioural group; 6 to 14 rats per group…Direct application onto the right L5 dorsal root ganglionNO-711 50 micrograms in 30 microlitres; oligodeoxynucleotid…Postoperative day 2, after thermal and mechanical hypersensitivity had been con…

Model: Right sciatic nerve crush injury (single 30 s crush with a serrated haemostat approximately 7 mm from nerve emergence)

Crush injury reduced ipsilateral L5 dorsal root ganglion alpha2 subunit expression by about 30% at day 2 and about 35% at day 10. Antisense knockdown worsened thermal and mechanical hypersensitivity in injured rats (days 3 to 6) and produced a neuropathic-like phenotype in sham animals, with an app…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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