Dose-escalation safety, tolerability and pharmacokinetic phase I study of Naoqingzhiming tablets (contains echinacoside 180 mg) in Chinese healthy subjects
Healthy Volunteers
Enrolment: 76 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy Volunteers
Enrolment: 76 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Dextran sulphate sodium (DSS)-induced acute colitis
Oral echinacoside-enriched extract significantly lowered disease activity index and prevented colonic damage, protecting the intestinal epithelium, with upregulated TGF-beta1 and increased Ki67-positive proliferating cells. The effect on inflammatory cellular infiltration was not significant.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.