THERAPY DOSSIER · th-f6bbb0eb5275

Basolateral amygdala electrical stimulation

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07785908 ↗EARLY_PHASE1not yet recruiting

Engaging the Amygdala With Brain Stimulation for PTSD

PTSD

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27262671 ↗2016Reported benefit

Amygdala electrical stimulation inducing spatial memory recovery produces an increase of hippocampal bdnf and arc gene expression.

RatOtherWistarMaleImplanted electrode, direct electrical stimulation of the basolateral amygdalaApplied after fimbria-fornix lesioning, 15 min after each daily water maze trai…

Model: Bilateral fimbria-fornix lesion causing spatial memory deficit

Daily basolateral amygdala electrical stimulation 15 min after water maze training produced partial recovery of spatial memory in fimbria-fornix lesioned rats, accompanied by increased hippocampal bdnf and arc gene expression. In non-lesioned untrained animals a single stimulation session caused a…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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