THERAPY DOSSIER · th-f5ef2a653cf3

Vascularised nerve graft

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01528397 ↗Injury indicationNAcompleted

Reconstruction of Proper Digital Nerve Defects in the Thumb Using a Pedicled Nerve Graft

Nerve Injury

Enrolment: 14 · Results not recorded

NCT01684839 ↗NAcompleted

Treatment of Painful Digital Neuroma Using a Pedicled Nerve Flap

Painful Digital Neuroma

Enrolment: 9 · Results not recorded

NCT01629602 ↗NAcompleted

Treatment of Soft Tissue Loss With Nerve Defect in the Finger Using the Boomerang Nerve Flap

Soft Tissue Loss With Nerve Defect

Enrolment: 49 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3968406 ↗1985Reported benefit

Experimental study of vascularized nerve grafts: multifactorial analyses of axonal regeneration of nerves transplanted into an acute burn wound.

RatBurnUnspecifiedSurgical transplantationGrafted into an acute burn wound

Model: Sciatic nerve grafting into an acute burn wound

Motor nerve conduction velocity was faster in vascularised than free nerve grafts up to week 24. Regenerated axons appeared earlier and the density of large regenerated axons was greater in the vascularised grafts. The authors suggest preserving the vascular system decreases fibrosis and allows smo…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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