THERAPY DOSSIER · th-f5d527e3fbca

Human central nervous system-derived neural stem cells (hCNS-SCns) combined with systemic neutrophil depletion using anti-Ly6G antibody

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02163876 ↗Injury indicationPHASE2terminated

Phase II study of human central nervous system stem cells (HuCNS-SC) transplantation in cervical spinal cord injury

Cervical Spinal Cord Injury

Enrolment: 31 · Results not recorded

NCT02467634 ↗PHASE2terminated

Phase II HuCNS-SC subretinal transplantation in geographic atrophy of age-related macular degeneration

Age-Related Macular Degeneration

Enrolment: 3 · Results not recorded

NCT00337636 ↗PHASE1completed

Phase I safety and preliminary effectiveness of human CNS stem cells (HuCNS-SC) in neuronal ceroid lipofuscinosis

Neuronal Ceroid Lipofuscinosis

Enrolment: 6 · Results not recorded

NCT01238315 ↗PHASE1withdrawn

Phase Ib allogeneic intracerebral human CNS stem cell transplantation in neuronal ceroid lipofuscinosis

Neuronal Ceroid Lipofuscinosis

Enrolment: 0 · Results not recorded

NCT02137915 ↗Phase not recordedterminated

Long-term follow-up of HuCNS-SC subretinal transplantation in geographic atrophy of AMD

Age-Related Macular Degeneration · Geographic Atrophy

Enrolment: 8 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28847814 ↗2017Mixed findings

Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair.

MouseSpinal cord injuryUnspecifiedFemaleAcute transplantation at 0 days post-injury, compared with previously reported…

Model: Spinal cord injury in an immunodeficient mouse model

Acute transplantation at 0 days post-injury produced localised astroglial differentiation near the lesion epicentre and failed to improve locomotor function, whereas specific immunodepletion of neutrophils with anti-Ly6G blocked astroglial differentiation and rescued the capacity of the transplante…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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