Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Radiation
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 7
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Multi-Center, Open-Label Randomized Study of Single or Double Myeloablative Cord Blood Transplantation With or Without Infusion of Off-The-Shelf Ex Vivo Expanded Cryopreserved Cord Blood Progenitor Cells in Patients With Haematologic Malignancies
Acute Lymphoblastic Leukemia in Remission · Acute Myeloid Leukemia in Remission · Chronic Myelogenous Leukemia · Myelodysplastic Syndrome
Enrolment: 163 · Results not recorded
Pilot Study: Infusion of Off-the-Shelf Ex Vivo Expanded Cryopreserved Progenitor Cells (Dilanubicel) in the Setting of Single Cord Blood Transplantation for Patients With Haematologic Malignancies
Acute Lymphoblastic Leukemia · Chronic Myelogenous Leukemia · Myelodysplastic Syndrome
Enrolment: 31 · Results not recorded
A Phase 2 Open-Label, Multi-Center, Randomized, Controlled, Dose-Finding Study of NLA101 in Adults Receiving High Dose Chemotherapy for Acute Myeloid Leukaemia
Leukemia, Myeloid, Acute
Enrolment: 146 · Results not recorded
Infusion of Off-the-Shelf Ex Vivo Expanded Cryopreserved Progenitor Cells (Dilanubicel) to Facilitate Engraftment of a Single CCR5delta32 Cord Blood Unit in Patients With HIV and Haematological Malignancies
Acute Myeloid Leukemia · HIV Infection · Myelodysplastic Syndrome · Non-Hodgkin Lymphoma
Enrolment: 1 · Results not recorded
Infusion of Off-the-Shelf Ex Vivo Expanded Cryopreserved Cord Blood Progenitor Cells to Augment Single or Double Myeloablative Cord Blood Transplantation in Patients With Haematologic Malignancies
Adult Acute Myeloid Leukemia in Remission · Myelodysplastic Syndromes · Chronic Myelogenous Leukemia
Enrolment: 15 · Results not recorded
Pilot Study Evaluating the Use of Ex Vivo Expanded Cord Blood Progenitors as Supportive Care Following Chemotherapy (FLAG) in Patients With AML or Acute Leukaemia of Ambiguous Lineage
Acute Leukemia of Ambiguous Lineage · Acute Myeloid Leukemia
Enrolment: 7 · Results not recorded
Clofarabine in Combination With Cytarabine and G-CSF Priming Followed by Infusion of Ex Vivo Expanded Cord Blood Progenitors for Patients With AML
Adult Acute Myeloid Leukemia
Enrolment: 29 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseRadiationBALB/cJ recipients; B6-Ly5a donors; C3H third-party skin graft donorsFemale recipients (donor B6-Ly5a mice were female or male)n = n = 12 per group for fresh cells; n = 10 to 15 for the 1 an…Intravenous1, 3, 5 or 15 x 10^6 expanded LSK cells per mouse; 5 x 10^6…2 to 4 hours after total body irradiation in the main experiments, with delayed…
Model: Haematopoietic acute radiation syndrome induced by a single dose of 6.5 to 8.5 Gy total body gamma irradiation from a caesium source at 81.4 cGy/min
Delta1-expanded cells gave high level donor engraftment by day 7 and improved survival after lethal total body irradiation in a cell dose-dependent manner (median survival 24 versus 14 days for fresh cells after 8.5 Gy). Cryopreserved cells at 5 x 10^6 given 2 to 4 hours after 7.5 to 8.5 Gy markedl…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
